If you need update bios, then Asus usually has the option to do so over the internet with ezupdate utility or over the internet from the bios itself.
The only reason we bring these things up is because there have been numerous Intel related issues that have warranted the need for micro code and bios updates. Such changes will often entail making changes to non obvious subsystems.
Microsoft does this for the OS through .NET updates as well as OS rebuilds based on those API subsystems.
This is also true for AMD systems where a bios update may also introduce changes that add security features or improvements and so on. Bios updates here often have a requisite chipset update on the new Ryzen platform ( though this is not your case ).
At this point I don't know what windows update is doing on your system. However...
To trouble short this problem, you can go into the system and security section ( where windows update is ) and check your update history. Here you can see if any updates have failed to apply - you can try to reinstall these.
It would help to know what the last update was ( KB####### ). And we can go from there.
Also there are two versions of .NET in use at the moment, 3.5sp1 and 4.8x series. You may find them here, also the core 2.2. Download .NET Framework | Free official downloads , you don't need the sdks just the runtimes. These are basically shared libraries that any program using the Microsoft operating system can utilize, and the fragmentation of the APIs can lead to unexpected behaviour in programs dependent on these shared libraries. Both versions can be found at the bottom of that page.
As for reference, windows updates have been documented here Windows 10 version history - Wikipedia . You may find you either have a failed update somewhere, or you simply need to look up the next update in the series and download and apply it manually. Get those .net runtimes first.
I vaguely recall one auto update KB??? had to be done like this, its probably a similar situation you are in.
