There was a case at the beginning of Ryzen's launch that required HPET be disabled, by AMD's own advice, to be disabled. However this was resolved and is no longer the case, and most motherboards do not even have an HPET toggle in BIOS, so don't worry about it, and any issue appears to affect Intel much more than AMD. HPET may even be removed entirely to be replaced by ITSC in the future, but it's not something that will receive much fanfare.
https://www.anandtech.com/show/12678/a-timely-discovery-examining-amd-2nd-gen-ryzen-results
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