First need to give more information about your computer setup, Make & model of each monitor, resolutions, and how they are connected to the computer.
What software are you using to configure the four Monitors? Eyefinity or Windows?
Are you using DP 1.2 with MST 1.2 to connect your monitors.? DisplayPort 1.2 Bandwidth only support four 1920 x1080 Resolution Monitors at one time.[DisplayPort Quick Guide] Daisy Chaining 2 to 4 Monitors - The World's Best PC Builder
Are you using a regular Windows 10 version or Windows for Server?
Here is the latest W4100 Professional Driver for your computer: AMD Radeon Pro Software for Enterprise 18.Q3 Release Notes | AMD
It is compatible with version 1803 and not 1709:
Compatible Operating Systems
AMD Radeon Pro Software for Enterprise 18.Q3 is designed to support the following Microsoft Windows platforms:
- Microsoft Windows® 10 (32-bit and 64-bit version RS4)
- Microsoft Windows® 7 (32-bit and 64-bit version with SP1 or higher)
- Microsoft Windows® Server 2016 (64-bit version)
- Microsoft Windows® Server 2008 R2 (64-bit version)