It will only happen in that game?
If so, looks like completely game related, but those games aren't that old and should run fine in todays machines. Running C&C Red Alert 2 (2000) from the CD is old but still works as the original HALO (2001), even System Shock 2 (1999).
Look for game patches as Red Alert 2 and System Shock 2 wont work on Windows 10 without them. It could help.
Try running it in windowed mode to see if the Windows is still responding in the background when it crashes, try other in game settings such as VSYNC or lower resolutions. Its all about troubleshooting.
Let me give you an example, my HALO installed from the original CD with VSYNC OFF its a complete mess, crashes, stutters and coil whine from the GPU. Disabling FreeSync from Adrenalin and Enabling VSYNC in the game and its a steady and a smooth game.
Its all about troubleshooting
Good Luck!
The Englishman