I should mention that:
I checked the integrity of the game files
Did a full re-install and deleted the %USERPROFILE%\Documents\Assassin's Creed Odyssey\ folder
I did a run where I disabled background applications and performed a clean reboot
Did a AMD cleanup of the drivers and re-installed the drivers
I also based on ThreeDee did:
Installed the latest AM4 chipset drivers
I have seperate power cables for each input
I have the latest GPU drivers
RAM is running at 2133 Mhz
Surface optimization is unchecked
I am not overclocking
CPU and GPU temperature are about 50 degrees and 55 degrees celcius
While I am encountering this issue