It is possible that the Adrenalin software is conflicting with the Windows hotkeys, causing them to become disabled. This could be due to the Adrenalin software using the same hotkeys for its own functions, or it may be a compatibility issue between the two programs.
To confirm whether this is the case, you can try disabling the Adrenalin software temporarily and testing the hotkeys again. If the hotkeys work without the Adrenalin software running, then it is likely that the software is causing the issue.
To disable the Adrenalin software temporarily, you can try closing the program or disabling it from starting up automatically when Windows boots. You can do this by opening the Task Manager and looking for the Adrenalin software under the "Startup" tab. From there, you can right-click on the program and select "Disable" or "End task" to stop it from running.
If the hotkeys still do not work even with the Adrenalin software disabled, then there may be another issue causing the problem. You can try updating your drivers and checking for any conflicts with other programs to see if that resolves the issue.