Exactly the same issue here.
Affects both Youtube videos, and Twitch streams when played fullscreen.
Ryzen 5600X, RX 6800, 3 monitors, Win10.
Primary Monitor is a Dell S2721DGF (2560x1440,165Hz, 10bit, SDR)
Secondary Monitors are both Dell U2412M (1920x1200, 60Hz, 8bit, SDR)
All connected via DisplayPort.
The OP's suggested solution appears to solve the issue.
Still needs to be urgently looked into by AMD though, as this is a mainstream use case!
- An AMD hardware stack from top to bottom; CPU, motherboard chipset, and GPU.
- the most popular web browser in the world.
- the most popular operating system in the world.
- the second most popular website in the world.
The only slightly atypical aspect to the system configuration is the presence of multiple monitors.
Though even that is close to being a majority amongst users with dedicated graphics cards.
I thought the days of glaring bugs in AMD GPU drivers was behind us?