Which Virus software you Use. I have a very Similar Problem that sometimes DLL's in games will get auto deleted because ... security. Not drivers like yours, Games Especially older games that used GAmes for windows live. Which are abandoned for the most part, the solution is a DLL that bypasses GFWL and Defender among others axes it not a word, try to run the exe and it pretends like you dont exist.
Check you AV's Quarantive for some DLL files that could have been pulled. its all I can think of for that sort of behavior. Something in that install has to be going missing. When this happens is windows still using the official AMD released driver or reverting to the Generic pnp driver. if it is, are you using unsigned custom drivers. If not install it agian, take a thourough inventory of the install package, and when it happens again, compare it see if something is gone. Its all I can think of to do.
Ryzen 5 3600 &--Crucial Ballistix 16GB--GTX 1080ti