If Radeon Settings feels unresponsive, there are a few troubleshooting steps you can try. First, ensure your graphics drivers are up to date by visiting AMD's website or using their software updater. If that doesn't help, try restarting your computer or reinstalling Radeon Settings. Sometimes, clearing temporary files or adjusting system settings can also improve responsiveness. If the issue persists, checking for conflicts with other software or consulting AMD support might be necessary to resolve the problem.