I did not uninstall the drivers for a quick first test and it worked for me. But to be on the safe side, and to prevent problems, I used the amd cleanup utility and reinstalled the drivers after, because I was curious how they performed (so far really not bad).
You can use ddu of course. I never really noticed any big difference between using the amd cleanup utility or ddu.
If you want to try the cleanup utility instead, here is a link (in case you worry about chipset drivers, don't worry. It is graphic drivers uninstallation only)