Having solved my previous Shadow of the Tomb Raider problem, I upgraded to a multi-gpu setup to drive a 1440p/144hz display.
Unfortunately it seems that I have to set Shadow Quality to 'Off' to avoid the game crashing to the desktop with DXGI_ERROR_DEVICE_HUNG when I try to continue the game or run the benchmark via Option -> Display and Graphics (though it does seem to occasionally work).
I went ahead and moved up to Windows 10 build 1809. I did uninstall the recent KB44282887 due to reports of degraded performance.
16GB Corsair Vengeance RAM (4x4, purchased as a kit)
Asus Z97 Pro WiFi ac Motherboard (Bios 5303)
2x PowerColor Red Dragon Vega 56
Samsung C27HG70 at 1440p
EVGA SuperNOVA 1200 watt Power Supply
Windows 10 build 1809
I'm on a clean install of Adrenalin 19.3.1.