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I have similar issues with my 6 monitor setup. I usually want to only use 3 monitors to as 1 display group for a wide-screen gaming setup.
With the help of the following post:
I've seen than no driver releases since 18.5.1 have the following directories in their release anymore:
Cant open advanced settings 18.3.1<ReleasePackageName>\Packages\Apps\CN
Looks like: C:\AMD\Win10-64Bit-Radeon-Software-Adrenalin-Edition-18.5.1-May23\Packages\Apps\CN
So the aforementioned article says to install <ReleasePackageName>\Packages\Apps\CN\CCCSlim\Core-Static-Net4\CCC-Slim.exe or CCC-slim.msi, but I tell you this doesn't always work. FYI, when AMD driver packages are installed, they uncompress and stay in C:\AMD. There you can see all of your past installed drivers.
I'm part of the Microsoft Insiders Program and the constant updates always either back-revs the AMD drivers and installs the Microsoft scaled-down version of the Radeon Adrenalin software.
What I do is install the 18.5.1 driver (Radeon Software Adrenalin Edition 18.5.1 Driver for Windows® 10 64-bit). It's the latest WHQL driver released from AMD. Everything newer (up to 18.10.1 at the time of this post) is a beta (optional) driver and does not have all of the AMD apps.
Install that driver (preferably as Custom -> Clean Install), rebooting as necessary. Install Relive if wanted when asked.
(My Dual R9 390 system hangs for long periods of time during the install and sometimes after initial reboot)
Then after installing 18.5.1, express install the latest driver over top the 18.5.1 driver, rebooted as necessary. Do not Clean Install. You should have a working Eyefinity -> Advanced Setup option.
When having the Advanced Setup open, you will see an AMD icon for the app on the taskbar. Right-click the icon and pin it to the taskbar for easier access.
In any subsequent Windows updates, if you click the icon and it doesn't open, then you know the CCC app or driver got hammered so it will not work again. Repeat the above process.