I installed these drivers today through the desktop app. Almost immediately I got ATIKMDAG.SYS bsod. I tried restore, but it didn't work. After a few tries my computer stayed on long enough for me to uninstall the graphics drivers and the bsod is gone.
Sapphire R9 270, AMD FX 6300, 16 gb ram, Windows 10 64 bit.
I would recommend rolling back your driver and waiting for the next update. When you do update when our next drivers release, please use DDU to remove your current driver for a clean installation.