I've noticed that IOMMU groups of ASRock X370 changed going from BIOS 3.10 to 4.50, noticeably
IOMMU Group 0 00:01.0 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) PCIe Dummy Host Bridge [1022:1452]
IOMMU Group 10 00:08.1 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Internal PCIe GPP Bridge 0 to Bus B [1022:1454]
IOMMU Group 11 00:14.0 SMBus [0c05]: Advanced Micro Devices, Inc. [AMD] FCH SMBus Controller [1022:790b] (rev 59)
IOMMU Group 11 00:14.3 ISA bridge [0601]: Advanced Micro Devices, Inc. [AMD] FCH LPC Bridge [1022:790e] (rev 51)
IOMMU Group 12 00:18.0 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Data Fabric: Device 18h; Function 0 [1022:1460]
IOMMU Group 12 00:18.1 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Data Fabric: Device 18h; Function 1 [1022:1461]
IOMMU Group 12 00:18.2 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Data Fabric: Device 18h; Function 2 [1022:1462]
IOMMU Group 12 00:18.3 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Data Fabric: Device 18h; Function 3 [1022:1463]
IOMMU Group 12 00:18.4 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Data Fabric: Device 18h; Function 4 [1022:1464]
IOMMU Group 12 00:18.5 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Data Fabric: Device 18h; Function 5 [1022:1465]
IOMMU Group 12 00:18.6 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Data Fabric Device 18h Function 6 [1022:1466]
IOMMU Group 12 00:18.7 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Data Fabric: Device 18h; Function 7 [1022:1467]
IOMMU Group 13 03:00.0 USB controller [0c03]: Advanced Micro Devices, Inc. [AMD] Device [1022:43b9] (rev 02)
IOMMU Group 13 03:00.1 SATA controller [0106]: Advanced Micro Devices, Inc. [AMD] Device [1022:43b5] (rev 02)
IOMMU Group 13 03:00.2 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] Device [1022:43b0] (rev 02)
IOMMU Group 13 1d:00.0 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] 300 Series Chipset PCIe Port [1022:43b4] (rev 02)
IOMMU Group 13 1d:01.0 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] 300 Series Chipset PCIe Port [1022:43b4] (rev 02)
IOMMU Group 13 1d:02.0 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] 300 Series Chipset PCIe Port [1022:43b4] (rev 02)
IOMMU Group 13 1d:03.0 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] 300 Series Chipset PCIe Port [1022:43b4] (rev 02)
IOMMU Group 13 1d:04.0 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] 300 Series Chipset PCIe Port [1022:43b4] (rev 02)
IOMMU Group 13 1d:06.0 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] 300 Series Chipset PCIe Port [1022:43b4] (rev 02)
IOMMU Group 13 1d:07.0 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] 300 Series Chipset PCIe Port [1022:43b4] (rev 02)
IOMMU Group 13 1f:00.0 Ethernet controller [0200]: Intel Corporation I211 Gigabit Network Connection [8086:1539] (rev 03)
IOMMU Group 13 20:00.0 USB controller [0c03]: Renesas Technology Corp. uPD720201 USB 3.0 Host Controller [1912:0014] (rev 03)
IOMMU Group 14 26:00.0 VGA compatible controller [0300]: NVIDIA Corporation GM206 [GeForce GTX 960] [10de:1401] (rev a1)
IOMMU Group 14 26:00.1 Audio device [0403]: NVIDIA Corporation Device [10de:0fba] (rev a1)
IOMMU Group 15 27:00.0 VGA compatible controller [0300]: NVIDIA Corporation GM107 [GeForce GTX 750 Ti] [10de:1380] (rev a2)
IOMMU Group 15 27:00.1 Audio device [0403]: NVIDIA Corporation Device [10de:0fbc] (rev a1)
IOMMU Group 16 28:00.0 Non-Essential Instrumentation [1300]: Advanced Micro Devices, Inc. [AMD] Device [1022:145a]
IOMMU Group 17 28:00.2 Encryption controller [1080]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Platform Security Processor [1022:1456]
IOMMU Group 18 28:00.3 USB controller [0c03]: Advanced Micro Devices, Inc. [AMD] USB3 Host Controller [1022:145c]
IOMMU Group 19 29:00.0 Non-Essential Instrumentation [1300]: Advanced Micro Devices, Inc. [AMD] Device [1022:1455]
IOMMU Group 1 00:01.3 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) PCIe GPP Bridge [1022:1453]
IOMMU Group 20 29:00.2 SATA controller [0106]: Advanced Micro Devices, Inc. [AMD] FCH SATA Controller [AHCI mode] [1022:7901] (rev 51)
IOMMU Group 21 29:00.3 Audio device [0403]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) HD Audio Controller [1022:1457]
IOMMU Group 2 00:02.0 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) PCIe Dummy Host Bridge [1022:1452]
IOMMU Group 3 00:03.0 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) PCIe Dummy Host Bridge [1022:1452]
IOMMU Group 4 00:03.1 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) PCIe GPP Bridge [1022:1453]
IOMMU Group 5 00:03.2 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) PCIe GPP Bridge [1022:1453]
IOMMU Group 6 00:04.0 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) PCIe Dummy Host Bridge [1022:1452]
IOMMU Group 7 00:07.0 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) PCIe Dummy Host Bridge [1022:1452]
IOMMU Group 8 00:07.1 PCI bridge [0604]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) Internal PCIe GPP Bridge 0 to Bus B [1022:1454]
IOMMU Group 9 00:08.0 Host bridge [0600]: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-0fh) PCIe Dummy Host Bridge [1022:1452]
Groups 20 and 21 are now separated. I've asked ASRock if they can separate the groups further, so all the PCIe slots would also have different groups, and they've said it's related to AGESA, so I should ask here.