I would start trying older drivers (or newer if you have older)
Mess with some settings like VSYNC, if its on one game only, probably its not the cards fault.
The latest adrenalin software also has a very comprehensive set of configurations that you can mess with.
My GPU in a very specific game screams out loud with coil whine although its an easy and very old game, I have to turn VSYNC on or Radeon Chill to keep it quiet. (for example)
The Englishman