This is my first AMD graphics card 6800 upgrade from a Nvidia 1060.
I definitely prefer Nvidia Game Filter... Whenever I tab out of a Windowed Fullscreen game on a Nvidia GPU with game filters on, it automatically goes to my default settings colors which I like to see when I'm browsing on youtube...etc.
Whereas AMD Radeon software game filter is on while you minimize the game and everything is over-saturated etc which is not pleasing to see when browsing.