It likely will work (given correct settings and other hardware).
You have not given much information so some random ideas on what could be the issue.
It could be a bios issue such as having it initialize the PCIe slot with the new card first this is usually the PEG option.
It could be your bios needs to be updated.
It could be your power supply doesn't meet the requirements for the card.
It could be the card wasn't all the way inserted.
I would check those things first. If none of that helps or you happen to have another pc handy try the card in another machine and see if it posts there.