Hopefully, you've got full backups of your data. If you don't, make a backup from the system as is.
As to your actual problem, there are at least two issues: first, unless you have a full, retail license of Windows (not OEM), you won't be able to re-activate your old license on your new hardware. As far as Microsoft is concerned, new motherboard = new computer (to say nothing of also having a new CPU). And, the OEM version of Windows is limited to one computer. Here's a link talking about that and some things to try:
https://helpdeskgeek.com/windows-10/how-to-replace-a-motherboard-without-reinstalling-windows-10/
If you do have a full, retail license, with such a massive change to the hardware, I'd recommend wiping that old install and doing a clean install. You can grab a copy here (I'd suggest doing your own search for that location and not trusting mine):
https://www.microsoft.com/en-us/software-download/windows10
Or, try:
https://support.microsoft.com/en-us/windows/give-your-pc-a-fresh-start-0ef73740-b927-549b-b7c9-e6f2b...
As for getting your existing installation to work, about the only thing I can suggest is going to Device Manager and deleting everything there. Reboot and run Windows Update until the blood runs clear, then install all your drivers again. But, I really would NOT recommend it. And, of course, after making sure of your data backup.
EDIT: oh, and since it's a new motherboard, update it's BIOS to the newest version from your manufacturer, reset it to defaults, and then set it to how you want it. Then head into Windows and try all the above (except the backup -- get that backup first).