Try this. I don't have 4k or anything but this works among my 3 monitors. I can set any one of them to be main display.
Right click desktop and choose display settings
At the top select the display you want to be "main display" (note it must be connected and have the large icon so extend or duplicate) and scroll down and you'll see a spot to checkmark "Make this my main display".
Then select your other display and scroll down to Multiple displays, and disconnect this display should be an option in the drop down menu. You can re-enable from the "project settings menu".
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