I've been using my 2013 Mac Pro for some time with dual FirePro D700's. The experience has been perfectly fine except with fullscreen applications... Changing focus to any other window while a fullscreen app is open will freeze Windows 10 and i have no choice but to hold the power button to force shut down. Ctrl + alt + delete only adds the loading wheel to the cursor before that freezes on me entirely. The music i am playing will continue to play.
Running Windows 10 22H2 build 19045.3155 with Radeon Pro driver 20.45.40.15 if it is relevant.