First time I ever used Eyefinity (which is recently) to consolidate 3 identical screens into one huge display for gaming it worked perfectly using "Quick Setup" and even gracefully reverted back to the original settings when "Deleted". The last couple of times, tho, it has crashed and failed to revert to the original settings when "Deleted" (black screen and lockup followed by problems on first boot after).
Recent windows 2021-04 Cumulative Update and a reinstall of the Radeon Driver Radeon-Software-Adrenalin-2020-21.3.1-Win10-64Bit-Mar24