In my case (RX6600, driver version is 24.20.19.05) VSR doesn't work in American Truck Simulator and Euro Truck Simulator 2 (worked before, even when I had another AMD graphic card). Usually, when I changed ingame resolution from native (1920x1080) to 4K and take screenshots - they were saved in 4K (yep, actual 4K, not blury upscale from FullHD). But for now, with latest 2 or 3 version of drivers it doesn't work. Now, when I change resolution to 4K - looks like nothing happens (usually it some quick flick of the screen meaning refresh of the picture, even overlay with fps meter and other graphic card info shrinks for like x2 smaller - it's a great example to make me sure 4K is actually turned ON) and numbers is only thing that was been changed. And you guys guess what? Screenshots saves in 1920x1080.
Looks like it happens from time to time, even with Nvidia cards (for example there was almost a year when VSR doesn't work, it worked in Forza Horizon 4 but doesn't work in Forza Horizon 5). There was a moment in the beginning of the year or spring when 4K is worked in FH5, but doesn't in older ones.
Don't want to throw any rocks at AMD but looks like they (who does the drivers) are the ones occasionally messing it up, not game developers with updates for their games (cause there was the moments when VSR in ON and with 4K resolution in some really old games (which doesn't had any updates) it works but suddenly doesn't for a few months).