When you plug in the USB HDD, what is showing in Device Manager?
Under USB category like on my older Asus Motherboard which uses ASMedia USB drivers:
Also look at Windows Event Viewer to see if there are any errors related to USB or to your External HDD.
Also I noticed that under MSI Support for your motherboard, Under Windows 7 it shows AMD USB 3.1 drivers: Support For B450M MORTAR MAX | Motherboard - The world leader in motherboard design | MSI Global
But I imagine since MSI didn't post any for Windows 10 USB 3.1 Drivers for your motherboard, It must be using Windows 10 native drivers.
If everything else works in your USB ports except your External HDD, either it isn't 100% compatible with your motherboard or Windows 10 since, at least, your Toshiba HDD is considered to be Legacy by Toshiba Support.
Maybe you should open a MSI Support and Toshiba Support tickets to find out if they can explain your situation with your external HDDs.