Usually when updating to the newer annual driver from previous annual version, it is suggested/recommended to clean install to the newer.
Download/save the newer full driver pkg direct from the amd driver page (not from the current installed app.).
Disconnect/unplug router/IP device to ensure MS doesn't override the update.
Disconnect the dell monitor from pc.
Start the driver install from the driver pkg, then choose custom > clean install.
After the final restart you can reconnect router/ip device.
Get your asus monitor set up again, then connect the dell and set it up.
My PC- Ryzen 5 5600x, B550 aorus pro ac, Hyper 212 black, 2 x 16gb F4-3600c16dgtzn kit, NM790 2TB, Nitro+RX6900XT, RM850, Win.10 Pro., LC27G55T.