I recently upgraded from a 5700 XT to the 6900 XT and PC works fine from cold boot and all games and applications work as expected. However, when waking the PC from S3 sleep, the PC hangs with the motherboard debug code 97 "console output devices connect".
Full System Specs:
X570 Crosshair VIII Hero (wifi) tested with bios 2311, 3003, 3101
64gb (4x16) 3200mhz G.Skill Ripjaws CL16 RAM
Ryzen 7 5800x
Corsair HX 1200w PSU
There are 3 AOC Agon 24" AG241QX monitors connected to the card via DP, DP, and USB-C to DP. There is also an Oculus Rift connected via HDMI but I've tested with the VR headset disconnected and get the same results.
I've also tested the 6900xt with an older X370 Crosshair VI Hero with Ryzen 7 3800x and see the same behavior.