I'm having a similar issue where i will launch a game or play a game then all of a sudden both monitors lose signal and i have to reboot to get image again, until it black screens again.
I've used the AMD uninstall too, DDU, I've even updated my bios, ram, and removed armory crate.
ASus x570-e Gaming Motherboard
Ryzen 9 5950x
ASUS Tuff 6900xt
64gb Corsair Vengence Ram
AMD Adrenalin Edition 22.11.2
Dual 4k Gigabyte M32UC Monitors
I've tried different display port cables and hdmi cables with the same issue.