This is very peculiar. I Just tried that with my RX580. After changing to two monitor eyefinity and doing a restart, it comes back with eyefinity still enabled and both monitors working. The difference I see is you're using an older version and I'm using 22.3.2.
Also, I'm still on win10 with identical displays.
So a couple otions:
1) update to latest version. Do a clean install with DDU.
2) discard eyefinity before a restart.
ASUS TUF X570 wifi, AMD Ryzen 5 5600G, ASRock 6700XT Challenger, Antec Truepower new 700w. 32GB