I have same problem while playing Helldivers 2.
5600X / 5700 XT.
Haven't found any solution, I have tried tracking Radeonsoftware.exe with procmon software and have found these problems:
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I was able to fix the above problem by deleting OpenVR folder, but there is still this problem:
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These both problems happen every cycle, ending up eating up to 60-70% CPU in worst cases, causing massive FPS drops in game.
I have tried deleting drivers with DDU and installing newest ones but same problem still exists. More people have similar problems with AMD systems + Helldivers 2 as seen here.