C:\AMD installation folder is safe to delete.
Every time you run a AMD Driver Package it creates C:\AMD folder. Every time you uninstall and install AMD Driver it adds to that folder.
That is why I always recommend to delete C:\AMD before installing a AMD Driver package. Whether the same one or a different one. This will prevent any future conflicts when you install a newer AMD driver version.
Plus it frees up anywhere from 500MB to several GBs of HDD/SSD space on your Windows Drive.