I have this issue on windows 11 (on windows 10 with newest update was the same). When system wakesup from "sleeps" amd adrenaline software not work - i must run it manually. I use it to play some games with eyefinity option, but when game off eyefinity hangs and when click, windows sent app crash report to microsoft, and then i even manually can't run adrenalien. Amd software and windows 11 don't cooperate properly imo.
Conecting all amd platform cpu with igpu (am5 r5 7600) and gpu (rx6600xt) from amd its not good idea
And the same gpu, but on old intel mobo with igpu, windows 10, and 24.7 amd driver and software works without issue.