I have been having shocking crash issues with Witcher 3 (both upgraded and DX11 versions). Only the game, not the system as such. I have experimented with various things and so far have had success with turning off FSR (2), which has given me a crash free experience in that game. I haven't had issues in others, so maybe only a Witcher thing.
I have a 7900XTX and run 2 1440p monitors, the main an ultrawide one btw.