This has been a long going issue for me and some others on AMD. Integer Scaling does not center the image and instead positions it to the top middle. With Integer Scaling off and Center scaling on the image will still not center and instead go to the top left. Windows Desktop with Integer Scaling actually does center the image so only fullscreen games have this issue.
I have tested in-game methods of Integer Scaling such as 1 from Diablo + Hellfire on GOG and its in-game method centers the image correctly. M Tanalin's Integer Scaler application that can only scale Windowed applications centers the image as well. AMD please get someone to review your Integer Scaling method as it is very inconsistent and needs to be addressed.480p Integer not in the center.720p (No idea why it's flipped, can't fix that.)