It shouldn't matter where the game is stored. When you launch it, Adrenalin should pick it up and let you tune the settings in the Gaming tab to your liking.
Ryzen 7 7800X3D, ASUS ROG STRIX X670E-F GAMING WIF, G.SKILL TRIDENT Z NEO 2x16GB DDR5 DRAM 6000MT/s CL30, AMD Radeon RX 7900 XTX, LIAN LI EDGE 1300, Corsair MP600 PRO NH 4TB