I use two monitors, one 4K 160Hz and one 4K 60Hz (both set to 150% scale).
The Radeon Overlay (Alt-R or Ctrl-Shift-O) never works for me ingame, except when I reinstall drivers - and then it stops working after the next reboot. Pressing Alt-R just freezes the game and shows my normal mouse pointer.
I noticed that if I sign out, turn off one monitor and then sign back in to Windows, the overlays now work as expected.
Does anyone else have this issue?
Running a 6800 XT on 21.4.1 drivers, but this issue has been plaguing me for a long time when I had a 5700 XT last year.