If I play a game or do somethink in Full Screen the color be inverted. Black and White are Normal.
I have installed the AMD Driver 20min Ago before I had only the catalyst control center. I never had a problem like this and hope that this is only a wrong setting.
Same problem here (R290X card), and I highly suspect this is an issue of a new driver. My previous driver was 19.10.2 and it did not have such problem. Upgraded to 20.12.1 and here I am.
First, I'm 100% sure this is an AMD problem, and not some kind of Windows issue or whatever.
Second, I must note that I only see this color issue in non-exclusive fullscreen games. In other words, the issue is present in borderless fullscreen games, and only in Unity engine. I've tried a couple of other games that support Borderless mode and didn't see the issue.
I suggest you to check if your game is in Borderless mode. E.g. you can try switching in and out of it with Alt+Tab and see if there is any blinking happens. Also check out a huge list of games that support Borderless mode - https://www.pcgamingwiki.com/wiki/List_of_games_that_support_borderless_fullscreen_windowed
The latest game with this issue for me is https://store.steampowered.com/app/1096100/Skellboy_Refractured/ - you can try the demo to see if you have this issue. That would mean there are at least two of us with this problem.
I'd really like this to be fixed somehow. There is this thread with a certain proposed workaround https://community.amd.com/t5/graphics/colors-inverted/td-p/245522 but sadly it won't work for me since I'm on Windows 8.1, and it doesn't have the "disable fullscreen optimization" compatibility option...
In the mean time I'll send a report using the AMD tool supplied with the driver.
Please let me know if you find some other solution, or if you find the exact driver version that started this bug.