Try enabling Virtual super Resolution and GPU scaling..
I have both of those enabled and don't have any problems..
Also check Samsung's website for a monitor driver if you don't have it..
AMD Ryzen 9 9900x, Asus Tuf Gaming RX 6700 XT, Asus Crosshair X870E Hero, 64gb Kingston DDR5 6000, Samsung 980pro 1tb NVME, Samsung 970 EVO Plus 1tb NVME, DeepCool Mystique 360 AIO, Antec Titanium 1000w.