Hi, the 5600XT released with only Maximum Display Support up to 4 Monitors. And you can use a splitter., dut the downside is that it will output the same image on the monitors used, rather than 2 different work-spaces or an expanded desktop. If that's fine, a splitter or daisy chain would do. Keep in mind, having displays at different refresh rates may reduce overall performance or create issues like black screen and sudden freezing, so have the same monitor on same refresh rates will better.
Though If you planning to have 6 separate work spaces, you should consider getting a GPU with 6 ports. If you are a creator, maybe the Radeon Pro Series will benefits you the most. Else if used for Gaming as well, the only GPU available across was the Radeon RX 5700 XT Taichi X 8G OC. This card is actually unusual in the six discrete output category in that it doesn’t feature exclusively Mini-DP ports.