Hi, i've been having trouble with these things. I've fixed most of them tweaking clocks and making profiles for each game/program.
For smite, try raising minimum clocks to a 100% and volt to 1070mv make it fixed 1600 mhz / 1070 mv. please answer back if this helped, cheers. I've done this on league of legends and i havent got a freeze in weeks, while i was having freezings every two or three matches.