I've been pulling my hair out for the past several weeks over this one.
I built a brand new PC, having been building them for a couple decades. This one has been giving me a nagging issue that I finally narrowed down to the Radeon driver.
I started with a Gigabyte B550 board with a AMD 5950X processor and 32GB DDR4.
I have the deep sleep option turned off, but left the monitors to turn off after 10 minutes.
After leaving the computer running, with the monitors blanked for 7-8 hours, when I wake the system back up (wiggle the mouse), all my desktop wallpaper is black, and the start menu is gone. If I right click on the task bar, I just get an empty menu.
Windows Explorer (explorer.exe) stops working. The only way to fix it is to pull up task manager and restart the explorer.exe process.
I've replaced the brand new motherboard with a different brand (Gigabyte B550 -> Asus B550), I've replaced the video card (5500XT -> 6700XT), replaced the RAM (Corsair -> GSkill).. even tried different monitors and display port cables.
Lastly, I replaced the videocard with an nVidia Quadro card, and ALL my issues went away.
This is clearly appears to be radeon driver issue.
Anyone else run into this issue? And if so, has anyone else found a work around?
If I run one monitor on HDMI and one on Display Port, the issue seems to go away. The only problem is I have three monitors, so two HAVE to be connected to display port. Ideally all 3 should be on display port.