Ran a lot of dual AMD GPU crossfire setups in my day.
Sometimes you have to factory reset/clean install the drivers/software to get them to communicate.
Also does your MOBO Support Crossfire.
Check your BIOS settings some MOBO's require that you manually set the PCIE x 16 slots from the primary at x16 to the primary and discrete at x8 and x8.
Make sure to save changes and reboot when performing new BIOS configurations.
You may need to update your MOBO BIOS as well to support the multi GPU setup especially with such late model/newer cards.
Check windows update ensure you are on the latest version and have the latest .Net Framework.
A clear CMOS could help.
A command Prompt run as admin sfc /scannow will check your OS for any corruptions or missing files and repair them. Always restart PC after this function has completed.
A command prompt run as admin CHKDSK C:/f will do a fast check of your storage devices for any errors and attempt to repair them. Note this will ask you a yes/no question to proceed and will only happen upon PC restart if you select y for yes.
Also try swapping your GPU's slots sometimes this helps.
If your GPU's have more than 1 HDMI output try different ports.
Also make sure under custom tuning in Adrenaline that your Primary and Discrete GPU fan control options are not set to zero RPM ( would advise setting them manually to 60 to 75%) as you could be facing thermal issues. These big boy cards heat up fast. AMD Adrenaline/Global Wattman has the Zero Fan RPM setting as default which is something AMD seriously needs to get rid of.
