Tried both 4K@60 and 4K@30
Other 2 monitors are 1080@60
4K and one 1080 monitor are DP -> DP
Other monitor is DP -> HDMI
So the FirePro W2100 has 2 DP ports. One DP port is straight to the 4K monitor. Second DP port has the MST hub plugged in:
Monoprice 2-Port DisplayPort 1.2 to DisplayPort Multi-Stream Transport (MST) Hub
First port is DP->DP monitor and second port is the DP->HDMI monitor.