Hi, I've been having the same issue with my Sapphire Nitro+ RX580 for a very long time, now.
But today, finally, I figured it out! Or at least further isolated where the issue may arise. It's something with the Full Installation. Reinstall, but choose Minimal instead. Problem gone, but so are the advanced features of the full software.
If that doesn't immediately work, might wish to to a clean uninstall before installing latest Minimal.