Having Instant Replay enabled causes subsecond stutters for me in games, while everything is running smoothly with it disabled.
I have ensured GameDVR is turned off.
This is easily and reliably reproducible with Unigine Superposition (4K Optimized).
Feel free to ask for more specific information to resolve this issue.
GPU: Gigabyte RX Vega 64 OC 8G
Radeon Software version: 18.6.1
Unigine Superposition build: 6181
OS: Windows 10 64-bit 1803 (build 17134.112)
CPU: Intel 6700K
Motherboard: Asus Maximus VIII Gene
RAM: 16GB @ 2133MHz
Disk speed (sequential): >100MB/s