Path of Exile 2 is very buggy with Adrenalin features, specifically Enhanced Sync and Anti-Lag, they cause various issues with the game.
For example, Path of Exile 2 doesn't work properly when BOTH Anti-Lag and Enhanced Sync are turned on together, more specifically, Anti-Lag somehow causes random micro-freezes, where the screen briefly freezes and Audio hangs up. Anti-Lag conflicts with Enhanced Sync when there is a background app running which works adjacent with Path of Exile 2, the FPS gets locked to my Monitor refresh rate. These issues are resolved when Anti-Lag is disabled.
More severe; Anti-Lag off by default, Enhanced Sync on, Enhanced Sync causes 'Cursor' to flicker or disappear randomly while in Path of Exile 2 the same randomly freezes and audio hang, I have ran into 3 BSOD(DRIVER_IRQL_NOT_LESS_OR_EQUAL) already, the .dmp file blamed it on "amdkmdag.sys", I have shared the file. When I disabled Enhanced Sync, all these issues were gone. I need Enhanced Sync as my game suffers from severe tearing or else, and since my Monitor Refresh rate is only 60Hz, limiting it is an unpleasant experience. Vysnc's input lag is too severe.
AMD Adrenalin Bug Report Data: Here
GPU was NOT overclocked ever.
Please, support Path of Exile 2, its a big game, and it will only get bigger, I am pretty sure the issues are far more than I have found myself.
BSOD Log
Overclock Settings