Suspect the AMD HD Audio is interfering with your USB-C audio device. Does your monitor have speakers? Both HDMI and DP can carry audio. Can try disabling the AMD HD Audio and make sure your Audient id14 is set as primary.
Here's another thread by someone who had a conflict with a USB headset, several options to try there although it appears did not resolve the issue.
Ryzen R7 5700X | B550 Gaming X | 2x16GB G.Skill 3600 | Radeon RX 7900XT
Ryzen R7 5700G | B550 Gaming X | 2x8GB G.Skill 4000 | Radeon Vega 8 IGP
Ryzen R5 5600 | B550 Gaming Edge | 4x8GB G.Skill 3600 | Radeon RX 6800XT