I am using the AMD High Def Audio Device through Display Port and have speakers plugged into the headphone out plug on my monitor..
Give it try, I also had to turn the volume on the monitor OSD up to full..
AMD Ryzen 7 3700x, Asus Tuf Gaming RX 6700 XT, Asus TUF Gaming x570 Plus, 32gb G.Skill TZ neo 3600mhz, Samsung 980pro 1tb NVME, Samsung 970 EVO Plus 1tb NVME, Lian Li Galahad AIO 240mm, Antec Titanium 1kw.