Using a 6600xt, either of the latest driver versions, if I have freesync enabled apps (such as discord, spotify, task manager) on my second screen will freeze when my GPU utilization is near 100%. This manifest most frequently in Overwatch. Doing something to reduce the GPU utilization such as opening the menu will unfreeze the apps until the GPU utilization goes up again. This is entirely resolved by disabling freesync on both monitors. After discord is frozen for long enough it goes black, and eventually drops out of any active call without even an audible notification to you, meaning you can suddenly be gone from a call while gaming without even realising.