After trying to fix this issue on and on for months I can confirm, forcing ryzen master to open on your main monitor does fix this! (had to disable my other monitors and then move the window to my main screen.
And yeah AMD please fix this, this makes the software unusable on a multi-monitor PC, and its most useful as a monitoring tool on a second monitor!
Processor: Ryzen 5950X
Motherboard: Asus ROG STRIX X570-E Gaming
OS: Windows 10 pro version 10.0.19042 Build 19042
Newest chipset drivers and ryzen master at the time of wriging