Try enabling Virtual super Resolution and GPU scaling..
I have both of those enabled and don't have any problems..
Also check Samsung's website for a monitor driver if you don't have it..
AMD Ryzen 9 9900x, Asus Prime X 9070, Asus Crosshair X870E Hero, 64gb Kingston DDR5 6000, Samsung 980pro 1tb NVME, Samsung 970 EVO Plus 1tb NVME, DeepCool Mystique 360 AIO, Antec Titanium 1000w.