Try enabling Virtual super Resolution and GPU scaling..
I have both of those enabled and don't have any problems..
Also check Samsung's website for a monitor driver if you don't have it..
AMD Ryzen 7 3700x, Asus Tuf Gaming RX 6700 XT, Asus TUF Gaming x570 Plus, 32gb G.Skill TZ neo 3600mhz, Samsung 980pro 1tb NVME, Samsung 970 EVO Plus 1tb NVME, Lian Li Galahad AIO 240mm, Antec Titanium 1kw.