This sounds more like a Windows issue than an AMD issue.
But to eliminate HDD hardware failure download Seagate's SEATOOLS for Windows or Toshiba's HDD's own diagnostic program and run their tests and see if it passes.
Also you can run CHKDSK /r/x to check your HDD disk for bad sectors.
If those HDD Diagnostic passes then I see that you have Asus AI Suite III installed. Disable or uninstall AI Suite III temporarily and see if your HDD disappears after sleep again.
I notice that you are running Windows 10 Enterprise LTSC 64-bit (10.0, Build 17763) (17763.rs5_release.180914-1434). That could be part of the problem since you are not using the latest version of Windows 10 with the latest Windows 10 updates. Possible Asus AI Suite III may not be completely compatible with that Windows OS version.
I read that Samsung Magician was the cause of this happening in a MS Forum thread: Secondary Hard Drive Disappears After Wake From Sleep Since - Microsoft Community
Also this Ten Forums has some good suggestions on how to prevent your HDD from disappearing after sleep: https://www.tenforums.com/drivers-hardware/68112-one-hdds-missing-disappeared-after-awaking-computer...